Sutent observational study

SUTENT® In The First Line Treatment Of Renal Cell ...

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4/16/2007 · SUTENT® In The First Line Treatment Of Renal Cell Carcinoma (SUNIKA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

SUTENT® In The First Line Treatment Of Renal Cell ...

(PDF) RETROSPECTIVE OBSERVATIONAL STUDY OF SUNITINIB ...

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retrospective observational study of sunitinib administered on schedule 2/1 in patients with metastatic renal cell carcinoma (mrcc): the rainbow study background

(PDF) RETROSPECTIVE OBSERVATIONAL STUDY OF SUNITINIB ...

A Retrospective Real World Analysis Of Sutent In Patients ...

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8/6/2013 · This is a retrospective, non-interventional study which looks at the cohort of Renal Cell Carcinoma patients in a real life clinical setting and analyses into factors why these patients have been surviving for as long as 3-5 years unlike Clinical study where the survival is around 2 years.

A Retrospective Real World Analysis Of Sutent In Patients ...

NCT00836745 | Renal Cell Carcinoma Clinical Trial | Pfizer

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The Sutent® Observational Study is being proposed to assess the real-world usage patterns and effectiveness and tolerability of treatment of Indian patients with advanced renal cell cancer with Sutent®. Generation of such information is expected to aid everyday clinical decision-making by Indian doctors and will add to the body of ...

NCT00836745 | Renal Cell Carcinoma Clinical Trial | Pfizer

Sunitinib for metastatic renal cell cancer patients ...

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Request PDF on ResearchGate | Sunitinib for metastatic renal cell cancer patients: Observational study highlighting the risk of important drug-drug interactions | What is known and objective ...

Sunitinib for metastatic renal cell cancer patients ...

Pazopanib versus Sunitinib in Metastatic Renal-Cell ...

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The study was a randomized, open-label, phase 3 trial of pazopanib (Votrient, GlaxoSmithKline) versus sunitinib (Sutent, Pfizer). Randomization was stratified according to Karnofsky performance ...

Pazopanib versus Sunitinib in Metastatic Renal-Cell ...

Management of side effects associated with sunitinib ...

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2/18/2009 · Advances in the understanding of the biology of renal cell carcinoma have led to recent approval of several new agents including drugs that target vascular endothelial growth factor. Sunitinib is an oral tyrosine kinase inhibitor which interferes with multiple intracellular tumorogenic pathways, and ...

Management of side effects associated with sunitinib ...

NCT02184416 | Metastatic Renal Cell Carcinoma (mRCC ...

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This is an international, multi-centre, prospective (partly retrospective), observational study to evaluate treatment patterns and clinical outcomes in patients with advanced or metastatic RCC treated with sunitinib in first line and/or receiving axitinib in second line post sunitinib.

NCT02184416 | Metastatic Renal Cell Carcinoma (mRCC ...

Sunitinib in the treatment of gastrointestinal stromal ...

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12/15/2016 · Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. In advanced setting and after progression to imatinib, the multi-targeted receptor tyrosine kinase inhibitor sunitinib has clearly demonstrated a clinical benefit in terms of response rate and progression-free survival with an acceptable toxicity profile.

Sunitinib in the treatment of gastrointestinal stromal ...

Dosing Information | SUTENT® (sunitinib malate) Capsules ...

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Find dosing information for SUTENT® (sunitinib malate), for the treatment of patients with advanced renal cell carcinoma. ... Rizzo M, et al. Retrospective observational study of sunitinib administered on schedule 2/1 in patients with metastatic renal cell carcinoma (mRCC): The rainbow study. J Clin Oncol. 2014;32(suppl 4):abstr 471.

Dosing Information | SUTENT® (sunitinib malate) Capsules ...

Sunitinib | C22H27FN4O2 - PubChem

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Sunitinib is multi-specific tyrosine kinase receptor inhibitor that is used in the therapy of gastrointestinal stromal tumors and advanced renal cell carcinoma. Sunitinib therapy is associated with transient elevations in serum aminotransferase and bilirubin levels and rare instances of …

Sunitinib | C22H27FN4O2 - PubChem

Experience with Sunitinib in metastatic renal cell ...

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pooled analysis from 3 Spanish observational prospective studies Daniel Castellanoa, José Pablo Marotob, Enrique Espinosac, ... (Sutent ©, Pfizer), an oral ... pivotal trial and in the expanded access study were also repro-

Experience with Sunitinib in metastatic renal cell ...

Sunitinib - National Institutes of Health

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6/27/2018 · Sunitinib is available in capsules of 12.5, 25 and 50 mg under the brand name Sutent. The typical dose of sunitinib is in cycles of 4 weeks, followed by a rest period of 2 weeks, using a starting dose of 37.5 or 50 mg daily and increasing or decreasing in 12.5 mg increments, with each cycle based upon tolerance and response.

Sunitinib - National Institutes of Health

A Study of Avelumab With Axitinib Versus Sunitinib In ...

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Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. Medical records research — uses ...

A Study of Avelumab With Axitinib Versus Sunitinib In ...

DEPARTMENT OF HEALTH AND HUMAN SERVICES Silver Spring …

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Finally, we have determined that only a clinical trial (rather than a nonclinical or observational study) will be sufficient to assess the signal of a serious risk of a decrease in overall survival of patients treated with Sutent ® (sunitinib malate) Capsules.

DEPARTMENT OF HEALTH AND HUMAN SERVICES Silver Spring …

Z9001 Adjuvant Gleevec Trial | GIST Support International

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2. Explain the result that caused the study to be unblinded: a difference in RFS of 97% for the imatinib group versus 83% for the placebo arm at the 1-year mark. The data show that at 1 year after entering the study the patients who took Gleevec had a significantly lower chance of recurrence.

Z9001 Adjuvant Gleevec Trial | GIST Support International

Clinical activity of sunitinib rechallenge in metastatic ...

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Study design. This was an observational, ambispective, multicentre study of patients who underwent sunitinib rechallenge between 2006 and 2013 at 19 participating centres in France. A retrospective and prospective study design was necessary to obtain a sufficient sample size in a reasonable timeframe. The primary end-point was PFS in rechallenge.

Clinical activity of sunitinib rechallenge in metastatic ...

Sorafenib in Advanced Hepatocellular Carcinoma | NEJM

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Background No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular ...

Sorafenib in Advanced Hepatocellular Carcinoma | NEJM

Sunitinib - an overview | ScienceDirect Topics

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In a prospective, observational cohort study in a tertiary-care hospital, there were abnormal serum TSH concentrations in 26 of 42 patients who took sunitinib for renal cell carcinoma or GIST. Persistent primary hypothyroidism, isolated TSH suppression, and transient mild rises in TSH were found in 36, 10, and 17% of patients respectively.

Sunitinib - an overview | ScienceDirect Topics

Renal side effects of VEGF-blocking therapy | Clinical ...

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12/17/2009 · Sunitinib (Sutent) is a VEGFR-2/-3 ... To test renal side effects under VEGF ablation therapy in a larger number of patients, we initiated an observational study with patients under sunitinib and bevacizumab treatment to look for glomerular proteinuria and podocyturia.

Renal side effects of VEGF-blocking therapy | Clinical ...

Food and Drug Administration Drug Approval Summary ...

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1/1/2007 · Study 1006 results were generated by independent, blinded review of radiographic images, whereas those from study 014 were from investigators. Secondary endpoints included duration of response, time to response, PFS, TTP, and overall survival. Study …

Food and Drug Administration Drug Approval Summary ...

Prospective study assessing hypoxia-related proteins as ...

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6/20/2013 · study population. The current work is a pre-planned observational prospective study aimed at the identification of molecular tumor markers of sunitinib efficacy in ccRCC, carried out in a population that was reported in an earlier study . In this previous study, 101 patients with RCC treated with first-line sunitinib were included to ...

Prospective study assessing hypoxia-related proteins as ...

Suresnes Cedex, France Clinical Research Trials | CenterWatch

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An Efficacy Study of Pomalidomide in Patient With Multiple Myeloma in Routine Clinical Practice . This study, a national, multicenter, observational, ambispective, non-interventional study, will be conducted in French hospitals prescribing pomalidomide and already participating in the ongoing Imnovid registry. This study will add to the registry.

Suresnes Cedex, France Clinical Research Trials | CenterWatch

The clinical implications of sunitinib-induced ...

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7/29/2008 · Patients and treatment schedule. Our single-centre, prospective, observational study included patients receiving sunitinib in the Department of …

The clinical implications of sunitinib-induced ...

Student's t-test - Wikipedia

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The t-test is any statistical hypothesis test in which the test statistic follows a Student's t-distribution under the null hypothesis.. A t-test is most commonly applied when the test statistic would follow a normal distribution if the value of a scaling term in the test statistic were known. When the scaling term is unknown and is replaced by an estimate based on the data, the test ...

Student's t-test - Wikipedia
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