Adacta study tocilizumab side

Genentech: Press Releases | Saturday, Nov 10, 2012

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11/10/2012 · About the ADACTA Study (Abstract #772) ADACTA (ADalimumab ACTemrA) is a Phase IV multi-center, randomized, double-blind, parallel group study designed to compare the reduction in signs and symptoms of RA in adult patients treated with either ACTEMRA or adalimumab as a …

Genentech: Press Releases | Saturday, Nov 10, 2012

Five-year Efficacy and Safety of Tocilizumab Monotherapy ...

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2/1/2017 · Objective. To report on the 5-year efficacy and safety results of the AMBITION (Actemra versus Methotrexate double-Blind Investigative Trial In mONotherapy) monotherapy study ([ClinicalTrials.gov][1]: [NCT00109408][2], [NCT00720798][3]). Methods. Patients with rheumatoid arthritis for whom biologics had not failed or who did not discontinue methotrexate because of lack of efficacy …

Five-year Efficacy and Safety of Tocilizumab Monotherapy ...

ADACTA Study Showed ACTEMRA Improved Signs and Symptoms …

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11/10/2012 · ADACTA Study Showed ACTEMRA Improved Signs and Symptoms of Rheumatoid Arthritis Significantly More Than Adalimumab as a Single-Agent Therapy -- In …

ADACTA Study Showed ACTEMRA Improved Signs and Symptoms …

Tocilizumab monotherapy versus adalimumab monotherapy for ...

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For example, the study ADACTA, which is the only head to head study between tocilizumab versus adalimumab (inhib- itor of TNF alpha), has shown a superior efficacy and a favourable safety profile ...

Tocilizumab monotherapy versus adalimumab monotherapy for ...

Tocilizumab - National Institutes of Health

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6/18/2015 · Tocilizumab is given by intravenous infusion every 4 weeks, in doses of 4-12 mg/kg depending upon indication and body weight. Tocilizumab is available in vials of 20 mg/mL under the brand name Actemra. The most frequent side effects are upper respiratory symptoms, headache, infusion reactions and hypertension. Hepatotoxicity

Tocilizumab - National Institutes of Health

Tocilizumab in the treatment of rheumatoid arthritis and ...

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3/28/2014 · Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by joint pain, swelling, stiffness, and progressive destruction of the small joints of the hands and feet. Treatment of RA has improved over the past decade. With multiple cytokines well-known now to play a role in the ...

Tocilizumab in the treatment of rheumatoid arthritis and ...

ADACTA Study Showed ACTEMRA Improved Signs and Symptoms …

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Results from the study showed ACTEMRA ® (tocilizumab) improved signs and symptoms (DAS28 score reduction) ... About the ADACTA Study (Abstract #772) ADACTA (ADalimumab ACTemrA) is …

ADACTA Study Showed ACTEMRA Improved Signs and Symptoms …

The AMBITION trial: Tocilizumab monotherapy for rheumatoid ...

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The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to tumour necrosis ...

The AMBITION trial: Tocilizumab monotherapy for rheumatoid ...

Biologic monotherapy in the treatment of rheumatoid arthritis

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5/14/2015 · In an early pilot study of ABA, a Phase II study with patients who were treated unsuccessfully with at least one DMARD, ABA monotherapy was compared to placebo ADA.35 There was a higher proportion of patients with American College of Rheumatology (ACR) 20 response in the treatment group with the highest ABA dosage of 10 mg/kg compared to ...

Biologic monotherapy in the treatment of rheumatoid arthritis

First Head-to-Head Biologic Trials for Rheumatoid Arthritis

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6/19/2012 · Dr. Cem Gabay describes the findings of his head-to-head comparison study between two biologic agents to treat rheumatoid arthritis. The ADACTA study found that tocilizumab was superior to ...

First Head-to-Head Biologic Trials for Rheumatoid Arthritis

[Full text] Tocilizumab in the treatment of rheumatoid ...

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10/11/2013 · The ADACTA study was a double-blind, randomized, placebo-controlled multicenter Phase IV trial that was the first head-to-head trial specifically designed to determine superiority between two biologic medications as monotherapy for the treatment of RA. 36 This trial evaluated the efficacy and safety of TCZ monotherapy versus adalimumab ...

[Full text] Tocilizumab in the treatment of rheumatoid ...

Roche's Actemra Beats Abbott Laboratories Drug in RA Trial ...

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Roche's Actemra Beats Abbott Laboratories Drug in RA Trial. ... Genentech, a member of the Roche Group (six:RO)(six:ROG)(otcqx:RHHBY), today announced data from the ADACTA study which showed that adult rheumatoid arthritis (RA) patients who received ACTEMRA (tocilizumab) as single-agent therapy (without other DMARDs) experienced a significantly ...

Roche's Actemra Beats Abbott Laboratories Drug in RA Trial ...

Tocilizumab in rheumatoid arthritis: A meta-analysis of ...

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The ADACTA study (Tocilizumab monotherapy vs. adalimumab monotherapy for treatment of rheumatoid arthritis: a randomized, double-blind study), a phase 4 superiority 24-week study, compared TCZ monotherapy to adalimumab, a TNFi, in patients who were intolerant to MTX or were inappropriate for continued MTX treatment .

Tocilizumab in rheumatoid arthritis: A meta-analysis of ...

Genentech: Press Releases | Tuesday, Jun 5, 2012

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6/5/2012 · Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced data from the ADACTA study which showed that adult rheumatoid arthritis (RA) patients who received ACTEMRA (tocilizumab) as single-agent therapy (without other DMARDs) experienced a significantly greater improvement in disease activity (DAS28 score reduction 1 ...

Genentech: Press Releases | Tuesday, Jun 5, 2012

Lead Investigator Discusses Implications of the GiACTA ...

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7/12/2016 · The most despised aspect of GCA for most patients is the need for long courses of glucocorticoids — and all of their attendant side effects — to treat GCA and try to prevent blindness and other disease complications. Summary & Clinical Applicability. A new phase III clinical trial shows the efficacy of tocilizumab in treating GCA.

Lead Investigator Discusses Implications of the GiACTA ...

Drug adherence, response and predictors thereof for ...

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12/13/2014 · This is in accordance with RCTs such as the ADACTA (ADalimumab ACTemrA) trial, suggesting tocilizumab provides good clinical response in monotherapy , and the ACT-RAY study, which demonstrated similar outcomes in patients with an inadequate MTX response, irrespective of whether tocilizumab was given as monotherapy or in combination with MTX ...

Drug adherence, response and predictors thereof for ...

Roche - Investor science conference call from EULAR 2012

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Investor science conference call from EULAR 2012 Berlin, 8 June 2012 . 2 ... side-effects of pipeline or marketed products; ... • ADACTA: A phase IV study evaluating the reduction in disease activity during monotherapy treatment with either Actemra or adalimumab

Roche - Investor science conference call from EULAR 2012

Efficacy and safety of monotherapy with sirukumab compared ...

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5/1/2018 · Based on the results of a phase 4, active-controlled study of tocilizumab monotherapy (the ADACTA study12) and assuming a treatment difference of 0.6–0.8 for the change from baseline in DAS28 at week 24 (SD of 1.6–1.8) and an ACR50 response rate at week 24 of 45%–50% with sirukumab versus 30% with adalimumab, a sample size of 170 patients ...

Efficacy and safety of monotherapy with sirukumab compared ...

Genentech’s ACTEMRA® Improved Rheumatoid Arthritis Signs ...

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SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced data from the ADACTA study …

Genentech’s ACTEMRA® Improved Rheumatoid Arthritis Signs ...

Efficacy of biological agents administered as monotherapy ...

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6/1/2015 · Efficacy of biological agents administered as monotherapy in rheumatoid arthritis: a Bayesian mixed-treatment comparison analysis Alberto Migliore,1 Emanuele Bizzi,1 Colin Gerard Egan,2 Mauro Bernardi,3 Lea Petrella4 1Rheumatology Unit, San Pietro Fatebenefratelli Hospital, Rome, 2Primula Multimedia SRL, Pisa, 3Department of Statistical Sciences, University of Padova, Padova, …

Efficacy of biological agents administered as monotherapy ...

Actemra reviews – Blog about body and health

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The overall evidence for tocilizumab (TCZ) for the treatment of large vessel vasculitis. Orencia subcutaneous rheumatoid. This review also examines the use of studies comparing therapies to. In the ADACTA study, which compared tocilizumab to adalimumab, the. Long-term efficacy and safety of tocilizumab in giant cell arteritis and large vessel.

Actemra reviews – Blog about body and health

Sarilumab - National Institutes of Health

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7/31/2017 · Sarilumab is available in single dose prefilled syringes of 150 and 200 mg in 1.14 mL under the brand name Kevzara. The most frequent side effects are upper respiratory symptoms, headache, infusion reactions and hypertension.

Sarilumab - National Institutes of Health

FDA approves first drug to specifically treat giant cell ...

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3/28/2018 · The U.S. Food and Drug Administration today expanded the approved use of subcutaneous Actemra (tocilizumab) to treat adults with giant cell arteritis. This new indication provides the first FDA ...

FDA approves first drug to specifically treat giant cell ...

GENENTECH'S ACTEMRA® IMPROVED RHEUMATOID ARTHRITIS …

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genentech's actemra® improved rheumatoid arthritis signs and symptoms significantly more than adalimumab as single-agent therapy south san francisco, calif. — june 5, 2012 —...

GENENTECH'S ACTEMRA® IMPROVED RHEUMATOID ARTHRITIS …

Monotherapy with biologic disease-modifying anti-rheumatic ...

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8/20/2016 · However, the only head-to-head study of biologic monotherapy in RA performed to date is the ADACTA study . Tocilizumab monotherapy was reported to have superior efficacy to adalimumab monotherapy for reduction of signs and symptoms of RA (DAS and Clinical Disease Activity Index), in patients for whom MTX was deemed inappropriate.

Monotherapy with biologic disease-modifying anti-rheumatic ...

Genentech's ACTEMRA® Shows Superiority in Rheumatoid ...

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Genentech's ACTEMRA® Shows Superiority in Rheumatoid Arthritis Signs and Symptoms Versus Adalimumab - read this article along with other careers information, tips and advice on BioSpace ... Genentech's ACTEMRA® Shows Superiority in Rheumatoid Arthritis Signs and Symptoms Versus Adalimumab. ... The safety profile of ACTEMRA in the ADACTA study ...

Genentech's ACTEMRA® Shows Superiority in Rheumatoid ...
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